El Centro is the center of San Serena. The district is home to many administrative and historical buildings, including the Palacio del Congreso, Plaza de la Republica and Catedral de San Pedro. The district is located on the north bank of the Acola River.
|Barrios of San Luis|
| Aravaca - Carcelén - Cuerabaca - El Centro - Esquina - Neuquén - Pasadiso - Puerto Guillerme|
Puerto Sassari - San Lorenzo - San Rafael - Villa Elisa - Villa García - Villa Mateo