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Puerto Guillerme is a borough of San Luis, located on the north bank of the Acola River. Formerly home to the city's port, the borough has been regenerated into a vibrant, trendy and multicultural area, with a large arts scene.

Barrios of San Luis
Aravaca - Carcelén - Cuerabaca - El Centro - Esquina - Neuquén - Pasadiso - Puerto Guillerme
Puerto Sassari - San Lorenzo - San Rafael - Villa Elisa - Villa García - Villa Mateo